MAT2530   Biology and Chemistry of Living Systems II   (10 credits)

Description

This course expands the range of biological systems covered that are core to the Cell and Human Biology element of the Biomaterials and Bioengineering courses. The following are included: the extracellular matrix; cell adhesion and spreading; cell communication and signalling; cytokines and HIV: complement activation and development of new biomaterials to improve biocompatibility; toxicity and toxicology including information on mutagenic effects, teratomas, carcinogens and neurotoxicity; classification of tumours, spread of tumours and clinical relevance. Two practical classes cover hands-on in vitro cell culture and toxicity testing of biomaterials. This unit aims to: investigate the extracellular matrix and its many functions; Investigate cell adhesion and spreading and how they are influenced by the physico-chemical characteristics of the underlying substrata; Provide an introduction to cell communication and cell-signalling, including information on hormones, local mediators, contact-dependent signalling molecules, and neurotransmitters; Explore the biological defences available at the cellular and systems level to injury, infection and materials; Provide a detailed knowledge of toxicity and toxicology, including information on mutagenic effects, teratomas, carcinogens and neurotoxicity.

Reading List